Ushbu hissa bemor namunalaridagi oqsillarni ularning to'planishi va shu bilan bog'liq alomatlarning oldini olish uchun o'rganishda dastlabki qadamdir. Eksperimental ma'lumotlar tadqiqotchilar tomonidan yaratilgan sichqonchani hayvon modelidan olingan bo'lib, u kasallik paytida oqsil bo'laklarining to'planishini ko'paytiradi.
Nashr etilgan ishda tadqiqotchilar ilmiy hamjamiyatda nrxnctf deb ataladigan sinaptik oqsil neyreksin fragmentiga e'tibor qaratdilar. Bu fragment oilaviy Altsgeymer 39 kasalligini keltirib chiqaradigan presenilin genidagi mutatsiya holatida to'planadi. Tadqiqotchilar hayvonlar modellarining miyasida ularning eksperimental to'planishi o'ziga xos xotira nuqsonlariga olib kelishi mumkinligini kuzatdilar. Ushbu kasalliklarning eksperimental modellari patogenezini aniqlash va samarali terapiya asoslarini loyihalash uchun juda muhimdir.
The researchers observed in behavioral studies that the accumulation of this protein leads to the loss of associative memory dependent on the brain39;s amygdala. In collaboration with Jos é Mar í a Delgado of the University of Pablo de oravide, synaptic connections from the prefrontal cortex to the amygdala were studied using electrophysiological records in mice. These experiments show that the accumulation of nrxnctf can also produce presynaptic plasticity defects.
Neyreksin
Neurexin is a transmembrane protein expressed in neurons and (neuroendocrine) cells. Neurexin exists in a variety of subtypes because they are encrypted by three genes, which are transcribed by two promoters and further modified by extensive alternative splicing. － Neurexin and － Neurexin protein consists of ligand binding domains that bind to several extracellular and intracellular interaction partners. Mouse genetics has proved － Neurexins play an important role in Ca2 plus reduce dependent synaptic transmission and a secondary role in synaptic formation. conversely, － Neurexins showed a strong potential to induce and differentiate synapses in cell culture experiments. Therefore, neurexin has become a key synaptic cell adhesion molecule and plays an important role in Ca2 plus reduce triggered release and synaptic development.
